Over the past several weeks, word has spread in professional circles about the resistance of most U.S. flu strains this year to the drug Tamiflu. Yesterday and today, the story has been picked up by the general media and, as usual, scary headlines abound.
Tamiflu (generic name: oseltamvir) is one of only 4 antiviral drugs available to treat influenza. With only 4 drugs in the armamentarium, resistance has always been a time bomb waiting to happen. Indeed, 2 others (of the 4 available drugs) have previously been plagued with resistance by flu strains and had largely fallen into disuse. Tamiflu was in many ways the most appealing of all the drugs because it can be given by mouth and can be used in children. The emergence of resistance to Tamiflu certainly speaks to the need for investment in the development of new medicines to treat flu (keep this in mind the next time you hear someone criticize the “greedy bad guys in the rich drug companies”).
So, is it now time to panic? Nope. First of all, this year’s flu season so far has been a mild one. Secondly, all flu drugs are, by definition, used primarily to TREAT rather than to PREVENT influenza infections. If appropriate PREVENTION steps are taken, the need to treat infection will be greatly reduced. Even now, flu drugs are not used very widely in the U.S. – they are typically given only for the worst cases and to the individuals most susceptible to severe complications when infected.
How to protect ourselves and our kids from flu? Four steps:
1. Flu vaccine. There’s still plenty of time and plenty of vaccine to go around for flu prevention this season. The vaccine has now been recommended for all kids between the ages of 6 months and 18 years. Most adults should also be vaccinated.
2. Personal hygiene and healthy lifestyle. Careful attention to handwashing, proper nutrition (plenty of vitamin C), adequate sleep, regular moderate exercise, and bundling up in the cold weather will greatly reduce the chances of getting the flu and will make the infection milder if you do get it. For lots of important details (and proof that these measures work), see earlier entries in Dr. Rotbart’s GERMBlog, as well as Chapters 9-11 in Germ Proof Your Kids – the Complete Guide to Protecting (without Overprotecting) Your Family from Infections (ASM Press, Washington, D.C., 2008).
3. Household hygiene. Disinfection of solid surfaces with bleach-containing household disinfectants will reduce the spread of flu among family members. Bleach, unlike other disinfecting substances, kills viruses (like influenza) as well as bacteria germs. Disinfecting wipes are great for those surfaces that don’t lend themselves to mops and sponges – doorknobs, frig handles, phone handsets, etc. Viruses can live on these surfaces for hours to a day or more (see previous posts on Dr. Rotbart’s GERMBlog and Chapter 9 in Germ Proof Your Kids.
4. School hygiene. Schools are uniquie “amplifiers” of influenza (see previous posts on Dr. Rotbart’s GERMBlog and Chapter 9 in bGerm Proof Your Kids. Once the first child in a school gets the infection, it spreads rapidly within the school and then out into the community and into your home. Speak with your kids’ school nurse and school administrators about steps they are taking in the classrooms, gym, and other common areas to reduce the spread of influenza. Refer them to the cover story I wrote for School Nurse News in the Back-to-School September edition, entitled “Germ Proof Your Schools”. Once again, disinfection with bleach-containing commercial disinfectants is central to prevention of spread in schools.
A fifth step could be added - be careful what you read and how you interpret the headlines. Remember, this newfound resistance of influenza to Tamiflu is not (NOT) about the dreaded Bird Flu pandemic that may or may not ever occur. The resistant strains this year are strains of “seasonal flu”, the variety of influenza infection that occurs every year. It is too early to say if next year’s strains will also be resistant, and it is impossible to predict yet how sensitive or resistant a Bird Flu strain might be in the future. For more on balancing prudence with paranoia when reading the news, see Chapter 12 in Germ Proof Your Kids.